CDK6 (cyclin-dependent kinase 6)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human CDK6.

Lyophilized powderWB: Antibody

Add 100ul of distilled water to this antibody before use.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28. and Schizosaccharomyces pombe cdc2. and are known to be important regulators of cell cycle

ATP + a protein = ADP + a phosphoprotein.

Contains 1 protein kinase domain. Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28 and Schizosaccharomyces pombe cdc2 and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase as well as CDK4 has been shown to phosphorylate and thus regulate the activity of tumor suppressor protein Rb. Mendrzyk. F. . (2005) J. Clin. Oncol. 23 (34). 8853-8862.