RABBIT ANTI PPAR ALPHA

PPAR ALPHA

Phosphate buffered saline pH7. 2

Synthetic peptide corresponding to amino acids 1 to 18 of mouse PPAR alpha.

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Ref. 8Ref. 11Subunit structureHeterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13. Interacts with PRDM16. Interacts with LIPN1. Ref. 5Ref. 6Ref. 7Ref. 9Ref. 10Subcellular locationNucleus. Tissue specificityHighly expressed in liver kidney and heart. Very weakly expressed in brain and testis. Developmental stageIt appears first at 13. 5 dpc and increases until birth. Involvement in diseaseNote=Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia. Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. 1. Fraser I. P. et al. (1993) Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature 364: 343-346. 2. de Villiers W. J. S. et al. (1994) Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function J. Exp. Med. 180: 705-709. 3. Hughes D. A. et al. (1995) Murine Macrophage Scavenger Receptor: in vivo expression and function as receptor for macrophage adhesion in lymphoid and non-lymphoid organs. Eur. J. Immunol. 25: 466-473. 4. Bell M. D. et al. (1994) Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS. J. Neurocytol. 23: 605-613. 5. Hughes D. A. et al. (1994) Murine Macrophage Scavenger Receptor: Adhesion function and Expression. Imm. Letts. 43: 7-14. 6. Rosen H. and Hughes D. A. (1995) Assays of Myeloid Cell Function Migration and adhesion in vivo. Weir Handbook of Experimental Immunology. London Blackwell Scientific Publications. 5th ed. In Press. 7. Daugherty A. et al. (2000) Polymorphism of class A scavenger receptors in C57BL/6 mice. J. Lipid Res 41: 1568 - 1577. [1] \" Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. \" Ashkenas J. Penman M. Vasile E. Acton S. Freeman M. W. Krieger M. J. Lipid Res. 34:983-1000(1993) [PubMed: 8394868] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS I AND II). [2] \" Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors. \" Doi T. Wada Y. Kodama T. Higashi K. I. Kurihara Y. Miyazaki T. Nakamura H. Uesugi S. Imanishi T. Kawabe Y. Itakura H. Yazaki Y. Matsumoto A. J. Biol. Chem. 268:2126-2133(1993) [PubMed: 8380589] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM II). [3] \" Identification of a functional domain in class A scavenger receptors that mediates metabolism of AcLDL. \" Rateri D. L. Whitman S. C. Block A. E. Daugherty A. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE (ISOFORM I). Strain: C57BL/6. [4] \" The transcriptional landscape of the mammalian genome. \" Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. Kodzius R. Shimokawa K. Bajic V. B. Brenner S. E. Batalov S. Forrest A. R. Zavolan M. Davis M. J. Wilming L. G. Aidinis V. Allen J. E. Ambesi-Impiombato A. Apweiler R. Aturaliya R. N. Bailey T. L. Bansal M. Baxter L. Beisel K. W. Bersano T. Bono H. Chalk A. M. Chiu K. P. Choudhary V. Christoffels A. Clutterbuck D. R. Crowe M. L. Dalla E. Dalrymple B. P. de Bono B. Della Gatta G. di Bernardo D. Down T. Engstrom P. Fagiolini M. Faulkner G. Fletcher C. F. Fukushima T. Furuno M. Futaki S. Gariboldi M. Georgii-Hemming P. Gingeras T. R. Gojobori T. Green R. E. Gustincich S. Harbers M. Hayashi Y. Hensch T. K. Hirokawa N. Hill D. Huminiecki L. Iacono M. Ikeo K. Iwama A. Ishikawa T. Jakt M. Kanapin A. Katoh M. Kawasawa Y. Kelso J. Kitamura H. Kitano H. Kollias G. Krishnan S. P. Kruger A. Kummerfeld S. K. Kurochkin I. V. Lareau L. F. Lazarevic D. Lipovich L. Liu J. Liuni S. McWilliam S. Madan Babu M. Madera M. Marchionni L. Matsuda H. Matsuzawa S. Miki H. Mignone F. Miyake S. Morris K. Mottagui-Tabar S. Mulder N. Nakano N. Nakauchi H. Ng P. Nilsson R. Nishiguchi S. Nishikawa S. Nori F. Ohara O. Okazaki Y. Orlando V. Pang K. C. Pavan W. J||?|| Pavesi G. Pesole G. Petrovsky N. Piazza S. Reed J. Reid J. F. Ring B. Z. Ringwald M. Rost B. Ruan Y. Salzberg S. L. Sandelin A. Schneider C. Schoenbach C. Sekiguchi K. Semple C. A. Seno S. Sessa L. Sheng Y. Shibata Y. Shimada H. Shimada K. Silva D. Sinclair B. Sperling S. Stupka E. Sugiura K. Sultana R. Takenaka Y. Taki K. Tammoja K. Tan S. L. Tang S. Taylor M. S. Tegner J. Teichmann S. A. Ueda H. R. van Nimwegen E. Verardo R. Wei C. L. Yagi K. Yamanishi H. Zabarovsky E. Zhu S. Zimmer A. Hide W. Bult C. Grimmond S. M. Teasdale R. D. Liu E. T. Brusic V. Quackenbush J. Wahlestedt C. Mattick J. S. Hume D. A. Kai C. Sasaki D. Tomaru Y. Fukuda S. Kanamori-Katayama M. Suzuki M. Aoki J. Arakawa T. Iida J. Imamura K. Itoh M. Kato T. Kawaji H. Kawagashira N. Kawashima T. Kojima M. Kondo S. Konno H. Nakano K. Ninomiya N. Nishio T. Okada M. Plessy C. Shibata K. Shiraki T. Suzuki S. Tagami M. Waki K. Watahiki A. Okamura-Oho Y. Suzuki H. Kawai J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM II). Strain: NOD. Tissue: Thymus. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM II). [6] \" An ancient highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. \" Freeman M. Ashkenas J. Rees D. J. Kingsley D. M. Copeland N. G. Jenkins N. A. Krieger M. Proc. Natl. Acad. Sci. U. S. A. 87:8810-8814(1990) [PubMed: 1978939] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 349-458. [7] \" Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line P388D. \" Aftring R. P. Freeman M. W. J. Lipid Res. 36:1305-1314(1995) [PubMed: 7666008] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-4. [8] \" The phagosomal proteome in interferon-gamma-activated macrophages. \" Trost M. English L. Lemieux S. Courcelles M. Desjardins M. Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract]Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; THR-34; SER-36 AND SER-40 MASS SPECTROMETRY. Tissue: Macrophage.