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PCSK2 Antibody (N-term)

PCSK2 Antibody (N-term)

Item no.	ABC-AP7617A
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, FC, IF, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PCSK2, PC2, NEC2, KEX2-like endoprotease 2, NEC 2, Neuroendocrine convertase 2, Prohormone convertase 2, Proprotein convertase 2
Available
Primary Accession	P16519
Antigen Type	Synthetic Peptide
Application	FC, IF, IHC-P, WB
Bio Background	PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.
Bio References	Leak, T.S., Keene, K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007) Shen, X., Li, Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005) Tzimas, G.N., Chevet, E. BMC Cancer 5, 149 (2005) Seidah, N.G., Mattei, M.G. Genomics 11 (1), 103-107 (1991)
Clonality	Polyclonal
Clone/Animal Names	RB18543
Gene ID	5126
Gene Name	PCSK2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Confocal immunofluorescent analysis of PCSK2 Antibody (N-term)(Cat#AP7617a) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Type image 1	IF
Dilution image 1	1:10~50
Legend image 2	Anti-PCSK2 Antibody (N-term) at 1:1000 dilution + TT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 71 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Western blot analysis of PCSK2 Antibody (N-term) (Cat. #AP7617a) in mouse cerebellum tissue lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.
Type image 3	WB
Dilution image 3	1:1000
Legend image 4	Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 4	IHC-P
Dilution image 4	1:10~50
Legend image 5	PCSK2 Antibody (N-term) (Cat. #AP7617a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 5	FC
Dilution image 5	1:10~50
Other Accession	P28841; Q03333; P21661
Predicted	Pig, Rat
Isotype	Rabbit Ig
Calculated MW	70565
Antigen Region	87-116
Antigen Source	HUMAN
Target/Specificity	This PCSK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the N-terminal region of human PCSK2.
NCBI Accession	NP_001188457.1; NP_001188458.1; NP_002585.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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