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ABL1 Antibody (N-term H246)

ABL1 Antibody (N-term H246)

Item no.	ABC-AP7694C
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB
Specific against	other
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ABL1, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL, JTK7
Available
Primary Accession	P00519
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9; 22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Bio References	Donaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99(22):14053-14058 (2002). Pisabarro, M.T., et al., J. Mol. Biol. 281(3):513-521 (1998). Nam, H.J., et al., Structure 4(9):1105-1114 (1996). Chissoe, S.L., et al., Genomics 27(1):67-82 (1995). Gosser, Y.Q., et al., Structure 3(10):1075-1086 (1995).
Clonality	Polyclonal
Clone/Animal Names	RB7355
Gene ID	25
Gene Name	ABL1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of ABL1 Antibody (N-term H246) (Cat.#AP7694c) in Y79 cell line lysates (35ug/lane). ABL1(arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Other Accession	P00520; F8W5Q8
Predicted	Zf, M
Isotype	Rabbit IgG
Calculated MW	122873
Antigen Region	231-260
Antigen Source	HUMAN
Target/Specificity	This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1.
NCBI Accession	NP_005148.2; NP_009297.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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