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Siramesine

Siramesine

Item no.	HY-14221-25mg
Manufacturer	MedChem Express
CASRN	147817-50-3
Amount	25 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Specific against	other
Purity	98.98
Smiles	FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1
Alias	Lu 28-179
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Sigma Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	454.58
Product Description	Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Neuronal Signaling
Clinical information	No Development Reported
Isoform	Sigma 1 Receptor

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