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Siramesine

Siramesine

Item no.	HY-14221-100mg
Manufacturer	MedChem Express
CASRN	147817-50-3
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 50 mg 5 mg
Category	Food Safety Hormones Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	Adv Sci (Weinh). 2023 Mar 11;e2300311. Dean Francis. 2023 Jun. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. Patent. US20220305013A1. [1]Perregaard J, et al. Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem. 1995;38(11):1998-2008. [2]Česen MH, et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013;4(10):e818. Published 2013 Oct 3. [3]Ostenfeld MS, et al. Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Autophagy. 2008;4(4):487-499.
Smiles	FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Lu 28-179
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Sigma Receptor
Shipping Temperature	Room temperature
Molecular Weight	454.58
Product Description	Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Neuronal Signaling
Isoform	Sigma 1 Receptor
Clinical information	No Development Reported

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Amount: 100 mg

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