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Colistin (sulfate)

Colistin (sulfate)

Item no.	HY-A0089-5g
Manufacturer	MedChem Express
CASRN	1264-72-8
Amount	5 g
Quantity options	100 mg 10 mM/1 mL 1 g 500 mg 5 g
Category	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Hancock RE et al. Peptide antibiotics. Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23.\|[2]Li J, et al. In vitro pharmacodynamic properties of colistin and colistin methanesulfonate againstPseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob Agents Chemother. 2001 Mar;45(3):781-5.\|[3]W S Yapa S, et al. Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections. Antimicrob Agents Chemother. 2013 Oct;57(10):5087-95.\|[4]Fleury MA, et al. Impact of two different colistin dosing strategies on healthy piglet fecal microbiota. Res Vet Sci. 2016 Aug;107:152-60. Adv Sci (Weinh). 2020 Jul 21;7(17):2001374.\|Animal Diseases. 02 November 2021.\|bioRxiv. 2025 January 19.\|bioRxiv. 2025 January 25.\|Cell Mol Gastroenterol Hepatol. 2025 Feb 7:101474.\|Clin Microbiol Infect. 2020 Sep;26(9):1264-1265.\|Hum Exp Toxicol. 2021 Apr 22;9603271211010906.\|J Antibiot (Tokyo). 2019 Aug;72(8):600-604. \|J Antibiot (Tokyo). 2025 Feb 5.\|Nat Commun. 2022 Mar 2;13(1):1116.\|Nat Commun. 2024 Sep 10;15(1):7914.\|Patent. US20200101105A1.\|Animal Diseases. 2024 Apr 3.\|Cell Host Microbe. 2024 May 13:S1931-3128(24)00137-9.\|Emerg Microbes Infect. 2024 Dec;13(1):2321981.\|Microorganisms. 2024 Mar 13, 12(3), 575.\|Vet Microbiol. 2024 May, 292, 110046.
Smiles	CCC(C)CCCC(N[C@@H](CCN)C(N[C@H](C(N[C@H](C(N[C@@H](CCNC([C@H]([C@H](O)C)N1)=O)C(N[C@@H](CCN)C(N[C@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCN)C(N[C@@H](CCN)C1=O)=O)=O)=O)=O)=O)=O)CCN)=O)[C@H](O)C)=O)=O.O=S(O)(O)=O.[2.5]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Polymyxin E (sulfate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Autophagy; Bacterial
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	1400.64
Product Description	Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.
Manufacturer - Research Area	Infection
Solubility	DMSO: < 1 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Autophagy
Clinical information	Launched

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HY-A0089-5g-safety-datasheet.pdf