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Rilmenidine (hemifumarate)

Rilmenidine (hemifumarate)

Item no.	HY-100490A-10mg
Manufacturer	MedChem Express
CASRN	207572-68-7
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Formula	C10H16N2O.1/2C4H4O4
Citations	[1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S. [2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180. [3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.
Smiles	O=C(O)/C=C/C(O)=O.C1(NC(C2CC2)C3CC3)=NCCO1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	207572-68-7
Similar products	207572-68-7
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Adrenergic Receptor; Apoptosis; Autophagy; Imidazoline Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen, away from moisture)
Molecular Weight	238.28
Product Description	Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].
Manufacturer - Research Area	Cancer; Cardiovascular Disease
Solubility	H2O : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Clinical information	Launched

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HY-100490A-10mg-safety-datasheet.pdf