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GR 113808

GR 113808

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-103152-50mg
CASRN	144625-51-4
Available
Product Description	GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.
StorageTemperature	-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	COVID-19-immunoregulation
Formula	C19H27N3O4S
References	[1].Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan; 111(1):332-8. \| [2].Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov; 151(5):933-944.e3.
MolecularWeight	393.5
Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 39 mg/mL (99.11 mM; Need ultrasonic and warming)
Target	5-HT Receptor
Isoform	5-HT4 Receptor; 5-HT1A Receptor; 5-HT3 Receptor; 5-HT2A Receptor; 5-HT2C Receptor
Pathway	GPCR/G Protein; Neuronal Signaling

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Amount: 50mg

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Delivery expected until 4/20/2023

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