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SID 26681509

SID 26681509

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-103353-50mg
CASRN	958772-66-2
Available
Product Description	SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neuromodulation
Formula	C27H33N5O5S
References	[1].Shah PP, et al. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol. 2008 Jul; 74(1):34-41. \| [2].Pribis JP, et al. The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88. Mol Med. 2015 Dec; 21(1):749-757.
MolecularWeight	539.65
Research Area	Cancer; Infection
Solubility	DMSO : 50 mg/mL (92.65 mM; Need ultrasonic)
Target	Cathepsin; Parasite
Isoform	Plasmodium
Pathway	Metabolic Enzyme/Protease; Anti-infection

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Amount: 50mg

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Delivery expected until 4/13/2023

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