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SID 26681509

SID 26681509

Item no.	HY-103353-1mg
Manufacturer	MedChem Express
CASRN	958772-66-2
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.70
Citations	iScience. 2024 Oct 4;27(11):111024. Nat Commun. 2020 Mar 27;11(1):1620. Nat Commun. 2022 May 26;13(1):2935. Signal Transduct Target Ther. 2021 Mar 27;6(1):134. Signal Transduct Target Ther. 2023 Oct 11;8(1):390. [1]Shah PP, et al. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol. 2008 Jul;74(1):34-41. [2]Pribis JP, et al. The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88. Mol Med. 2015 Dec;21(1):749-757.
Smiles	O=C(NNC(SCC(NC1=CC=CC=C1CC)=O)=O)[C@H](CC2=CNC3=CC=CC=C23)NC(OC(C)(C)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	958772-66-2
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Cathepsin; Parasite
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	539.65
Product Description	SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G[1].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Metabolic Enzyme/Protease
Isoform	Cathepsin L; Leishmania; Plasmodium
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-103353-1mg-safety-datasheet.pdf