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CYM5442

CYM5442

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-10968-100mg
CASRN	1094042-01-9
Available
Product Description	CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS).
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Neuroscience-Neuromodulation
Formula	C23H27N3O4
References	[1].Gonzalez-Cabrera PJ, et al. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov; 74(5):1308-18. \| [2].Blanco R, et al. The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss. Exp Eye Res. 2017 Nov; 164:37-45.
MolecularWeight	409.48
Research Area	Neurological Disease
Solubility	DMSO : 2.63 mg/mL (6.42 mM; Need ultrasonic)
Target	LPL Receptor
Pathway	GPCR/G Protein

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Amount: 100mg

available

Delivery expected until 4/20/2023

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