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SCH529074

SCH529074

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	25 mg
Item no.	HY-110088-25mg
CASRN	922150-11-6
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 μM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC)[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	563.56
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 20 mg/mL (ultrasonic)
Manufacturers Target	MDM-2/p53
Pathway	Apoptosis
Manufacturers Product type	Reference compound

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