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SCH529074

SCH529074

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-110088-50mg
CASRN	922150-11-6
Available
Product Description	SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 μM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC).
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Cancer-programmed cell death
Formula	C31H36Cl2N6
References	[1].Miljana Nenkov, et al. Growth Inhibitory Role of the p53 Activator SCH 529074 in non‑small Cell Lung Cancer Cells Expressing Mutant p53. Oncol Rep. 2020 Jun; 43(6):2073-2082. \| [2].Mark Demma, et al. SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-Suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53. J Biol Chem. 2010 Apr 2; 285(14):10198-212.
MolecularWeight	563.56
Research Area	Cancer
Target	MDM-2/p53
Pathway	Apoptosis

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Amount: 50mg

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Delivery expected until 4/13/2023

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