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NF449 (octasodium)

NF449 (octasodium)

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10 mg
Item no.	HY-112461A-10mg
CASRN	627034-85-9
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs[1][2].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	1505.09
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease
Solubility	H2O : 10 mg/mL (ultrasonic; warming)\|DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	P2X Receptor
Isoform	P2X1 Receptor
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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