Comparison

NF449 octasodium European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-112461A-50mg
CASRN 627034-85-9
Available
Product Description
NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs.
StorageTemperature
-20°C, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Applications
Neuroscience-Neuromodulation
Formula
C41H24N6Na8O29S8
References
[1].Rettinger J, et al. Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology. 2005; 48(3):461-468. | [2].Hechler B, et al. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4, 4', 4'', 4'''-(carbonylbis(imino-5, 1, 3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1, 3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther. 2005; 314(1):232-243. | [3].Hohenegger M, et al. Gsalpha-selective G protein antagonists. Proc Natl Acad Sci U S A. 1998; 95(1):346-351.
MolecularWeight
1505.09
Research Area
Cardiovascular Disease
Target
P2X Receptor
Pathway
Membrane Transporter/Ion Channel

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/20/2023 

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