P53R3

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	HY-122578-10mg
CASRN	922150-12-7
Available
Product Description	P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Cancer-programmed cell death
Formula	C32H35Cl2N5O2
References	[1].Alejandro Parrales, et al. Targeting Oncogenic Mutant p53 for Cancer Therapy. Front Oncol
MolecularWeight	592.56
Research Area	Cancer
Target	MDM-2/p53
Pathway	Apoptosis

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Amount: 10mg

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Delivery expected until 4/13/2023

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