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Bisindolylmaleimide VIII (acetate)

Bisindolylmaleimide VIII (acetate)

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10 mg
Item no.	HY-129624A-10mg
CASRN	138516-31-1
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[2].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	458.51
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; PKC
Isoform	PKC; PKCα; PKCβ; PKCγ; PKCε
Pathway	Apoptosis; Epigenetics; TGF-beta/Smad
Manufacturers Product type	Reference compound

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