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Bisindolylmaleimide VIII acetate

Bisindolylmaleimide VIII acetate

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-129624A-50mg
CASRN	138516-31-1
Available
Product Description	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
StorageTemperature	-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	COVID-19-immunoregulation
Formula	C26H26N4O4
References	[1].Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1; 294 ( Pt 2):335-7. \| [2].Ohtsuka T, et al. Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. J Biol Chem. 2002 Aug 9; 277(32):29294-303.
MolecularWeight	458.51
Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (545.24 mM; Need ultrasonic)
Target	PKC; Apoptosis
Isoform	Rat Brain PKC; PKC-α; PKC-βI; PKC-βII; PKC-γ; PKC-ε
Pathway	Epigenetics; TGF-beta/Smad; Apoptosis

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Amount: 50mg

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Delivery expected until 4/6/2023

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