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Bisindolylmaleimide VIII (acetate)

Bisindolylmaleimide VIII (acetate)

Item no.	HY-129624A-50mg
Manufacturer	MedChem Express
CASRN	138516-31-1
Amount	50 mg
Quantity options	10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.68
Formula	C26H26N4O4
Citations	[1]Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1;294 ( Pt 2):335-7. [2]Ohtsuka T, et al. Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. J Biol Chem. 2002 Aug 9;277(32):29294-303.
Smiles	O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O.CC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Ro 31-7549 (acetate), Bis VIII (acetate)
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; PKC
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	458.51
Product Description	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively[1]. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases[2].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Epigenetics; TGF-beta/Smad
Isoform	PKC; PKCα; PKCβ; PKCγ; PKCε
Clinical information	No Development Reported

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HY-129624A-50mg-safety-datasheet.pdf