Comparison

Bisindolylmaleimide VIII acetate European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-129624A-50mg
CASRN 138516-31-1
Available
Product Description
Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
StorageTemperature
-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
COVID-19-immunoregulation
Formula
C26H26N4O4
References
[1].Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1; 294 ( Pt 2):335-7. | [2].Ohtsuka T, et al. Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways. J Biol Chem. 2002 Aug 9; 277(32):29294-303.
MolecularWeight
458.51
Research Area
Cancer; Inflammation/Immunology
Solubility
DMSO : 250 mg/mL (545.24 mM; Need ultrasonic)
Target
PKC; Apoptosis
Isoform
Rat Brain PKC; PKC-α; PKC-βI; PKC-βII; PKC-γ; PKC-ε
Pathway
Epigenetics; TGF-beta/Smad; Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/6/2023 

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