IMT1

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	100 mg
Item no.	HY-134539-100mg
Targets	Mitochondrial Metabolism; DNA/RNA Synthesis
CASRN	2304621-31-4
eClass 6.1	30220300
eClass 9.0	32160605
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Product Description	IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	351.40
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Metabolic Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturers Target	DNA/RNA Synthesis; Mitochondrial Metabolism; Oxidative Phosphorylation
Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Manufacturers Product type	Reference compound

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