IMT1

Item no.	HY-134539-25mg
Manufacturer	MedChem Express
CASRN	2304621-31-4
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.13
Citations	[1]Nina A Bonekamp, et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716.
Smiles	CC(OC1=CC=C(C(O2)=C1)C(C3=CC=CC=C3C)=CC2=O)C(N(C)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2304621-31-4
Similar products	2304621-31-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	DNA/RNA Synthesis; Mitochondrial Metabolism; Oxidative Phosphorylation
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	351.40
Product Description	IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1].
Manufacturer - Research Area	Cancer; Metabolic Disease
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-134539-25mg-safety-datasheet.pdf