Comparison

Banoxantrone dihydrochloride European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-13562A-50mg
CASRN 252979-56-9
Available
Product Description
Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
StorageTemperature
-20°C, protect from light, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Applications
Cancer-programmed cell death
Formula
C22H30Cl2N4O6
References
[1].Hejmadi MV, et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer. 1996 Feb; 73(4):499-505. | [2].Manley E Jr, et al. Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. J Pharmacol Exp Ther. 2013 Feb; 344(2):368-77. | [3].Williams KJ, et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. Mol Cancer Ther. 2009 Dec; 8(12):3266-75.
MolecularWeight
517.4
Research Area
Cancer
Solubility
DMSO : 12.5 mg/mL (24.16 mM; Need ultrasonic) | H2O : 9.52 mg/mL (18.40 mM; ultrasonic and warming and heat to 60°C)
Target
Topoisomerase
Isoform
Topoisomerase II
Pathway
Cell Cycle/DNA Damage

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/6/2023 

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