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Banoxantrone dihydrochloride

Banoxantrone dihydrochloride

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	50mg
Item no.	HY-13562A-50mg
CASRN	252979-56-9
Available
Product Description	Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
StorageTemperature	-20°C, protect from light, stored under nitrogen; In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Applications	Cancer-programmed cell death
Formula	C22H30Cl2N4O6
References	[1].Hejmadi MV, et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer. 1996 Feb; 73(4):499-505. \| [2].Manley E Jr, et al. Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. J Pharmacol Exp Ther. 2013 Feb; 344(2):368-77. \| [3].Williams KJ, et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. Mol Cancer Ther. 2009 Dec; 8(12):3266-75.
MolecularWeight	517.4
Research Area	Cancer
Solubility	DMSO : 12.5 mg/mL (24.16 mM; Need ultrasonic) \| H2O : 9.52 mg/mL (18.40 mM; ultrasonic and warming and heat to 60°C)
Target	Topoisomerase
Isoform	Topoisomerase II
Pathway	Cell Cycle/DNA Damage

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Amount: 50mg

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Delivery expected until 4/6/2023

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