SAE-14

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	HY-147222-10mg
CASRN	1241280-25-0
Available
Product Description	SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	COVID-19-immunoregulation
Formula	C19H19F3N2O2
References	[1].Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov; 375(2):367-375.
MolecularWeight	364.36
Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)
Target	EBI2/GPR183
Pathway	GPCR/G Protein

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Amount: 10mg

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Delivery expected until 4/13/2023

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