Comparison

SAE-14 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 10mg
Item no. HY-147222-10mg
CASRN 1241280-25-0
Available
Product Description
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
StorageTemperature
Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications
COVID-19-immunoregulation
Formula
C19H19F3N2O2
References
[1].Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov; 375(2):367-375.
MolecularWeight
364.36
Research Area
Inflammation/Immunology; Neurological Disease
Solubility
DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)
Target
EBI2/GPR183
Pathway
GPCR/G Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 10mg
Available: In stock
available

Delivery expected until 4/13/2023 

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