Comparison

SAE-14 European Partner

Item no. HY-147222-25mg
Manufacturer MedChem Express
CASRN 1241280-25-0
Amount 25 mg
Quantity options 100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 98.26
Formula C19H19F3N2O2
Citations [1]Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375.
Smiles O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias GPR183 antagonist-1
Available
Product Description
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1].
StorageTemperature
-20°C, 3 years (Powder)
Shipping
Blue Ice
Manufacturers Applications
COVID-19-immunoregulation
MolecularWeight
364.36
Clinical Information
No Development Reported
Manufacturers Research Area
Inflammation/Immunology; Neurological Disease
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Target
EBI2/GPR183
Manufacturers Target
EBI2/GPR183
Manufacturers Pathway
GPCR/G Protein
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 mg
Available: In stock
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