SAE-14

Item no.	HY-147222-25mg
Manufacturer	MedChem Express
CASRN	1241280-25-0
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.26
Formula	C19H19F3N2O2
Citations	[1]Kathryn Braden, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375.
Smiles	O=C(NC1=CC(N2CCOCC2)=CC(F)=C1)CCC3=CC=C(F)C(F)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GPR183 antagonist-1
Available
Product Description	SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	364.36
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Target	EBI2/GPR183
Manufacturers Target	EBI2/GPR183
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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