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Auristatin E

Auristatin E

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	250mg
Item no.	HY-15582-250mg
CASRN	160800-57-7
Available
Product Description	Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; The compound is unstable in solutions, freshly prepared is recommended.
Applications	Cancer-programmed cell death
Formula	C40H69N5O7
References	[1].Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15; 102(4):1458-65. \| [2].Li D, et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther. 2013 Jul; 12(7):1255-65.
MolecularWeight	732.01
Research Area	Cancer
Solubility	DMSO : 100 mg/mL (136.61 mM; Need ultrasonic)
Target	Microtubule/Tubulin; ADC Cytotoxin
Isoform	Auristatin
Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Antibody-drug Conjugate/ADC Related

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Amount: 250mg

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Delivery expected until 4/13/2023

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