Comparison

Auristatin E European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 250mg
Item no. HY-15582-250mg
CASRN 160800-57-7
Available
Product Description
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; The compound is unstable in solutions, freshly prepared is recommended.
Applications
Cancer-programmed cell death
Formula
C40H69N5O7
References
[1].Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15; 102(4):1458-65. | [2].Li D, et al. DCDT2980S, an anti-CD22-monomethyl auristatin E antibody-drug conjugate, is a potential treatment for non-Hodgkin lymphoma. Mol Cancer Ther. 2013 Jul; 12(7):1255-65.
MolecularWeight
732.01
Research Area
Cancer
Solubility
DMSO : 100 mg/mL (136.61 mM; Need ultrasonic)
Target
Microtubule/Tubulin; ADC Cytotoxin
Isoform
Auristatin
Pathway
Cell Cycle/DNA Damage; Cytoskeleton; Antibody-drug Conjugate/ADC Related

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 250mg
Available: In stock
available

Delivery expected until 4/13/2023 

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