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c-Kit-IN-5-1 European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 5mg
Item no. HY-18302-5mg
CASRN 1003311-62-3
Available
Product Description
c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications
COVID-19-immunoregulation
Formula
C23H17N5O2
References
[1].Hu E, et, al. Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit. J Med Chem. 2008 Jun 12; 51(11):3065-8.
MolecularWeight
395.41
Research Area
Inflammation/Immunology
Solubility
DMSO : 25 mg/mL (63.23 mM; ultrasonic and warming and heat to 80°C)
Target
c-Kit
Pathway
Protein Tyrosine Kinase/RTK

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 5mg
Available: In stock
available

Delivery expected until 4/13/2023 

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