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c-Kit-IN-5-1

c-Kit-IN-5-1

Item no.	HY-18302-5mg
Manufacturer	MedChem Express
CASRN	1003311-62-3
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.16
Formula	C23H17N5O2
Citations	[1]Hu E, et, al. Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit. J Med Chem. 2008 Jun 12;51(11):3065-8.
Smiles	O=C1C(C2=CC3=CN=C(N)N=C3C=C2)=C(C)C=CN1C4=CC=C(C5=NC=CO5)C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	c-Kit
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	395.41
Product Description	c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported

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HY-18302-5mg-safety-datasheet.pdf