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c-Kit-IN-5-1

c-Kit-IN-5-1

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	5mg
Item no.	HY-18302-5mg
CASRN	1003311-62-3
Available
Product Description	c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties.
StorageTemperature	Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications	COVID-19-immunoregulation
Formula	C23H17N5O2
References	[1].Hu E, et, al. Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit. J Med Chem. 2008 Jun 12; 51(11):3065-8.
MolecularWeight	395.41
Research Area	Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (63.23 mM; ultrasonic and warming and heat to 80°C)
Target	c-Kit
Pathway	Protein Tyrosine Kinase/RTK

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Amount: 5mg

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Delivery expected until 4/13/2023

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