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Kauran-16,17-diol

Kauran-16,17-diol

Item no.	HY-N7422-1ea
Manufacturer	MedChem Express
CASRN	16836-31-0
Amount	1 ea
Quantity options	10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.51
Citations	[1]Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52.\|[2]Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.
Smiles	C[C@]1(CCC2)[C@@]3([H])[C@](C[C@H]4CC3)(CC[C@]1([H])C2(C)C)C[C@]4(O)CO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ent-Kauran-16β,17-diol
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	306.48
Product Description	Kauran-16, 17-diol (ent-Kauran-16β, 17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-N7422-1ea-safety-datasheet.pdf