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Olomoucine European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-W011428-50mg
CASRN 101622-51-9
Available
Product Description
Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM). Olomoucine regulates cell cycle and shows anti-melanin tumor activity.
StorageTemperature
Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month
Applications
Cancer-Kinase/protease
Formula
C15H18N6O
References
[1].Hajdúch M, et al. Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine. Anticancer Drugs. 1997 Nov. 8(10):1007-13. | [2].Raynaud FI, et al. Cassette dosing pharmacokinetics of a library of 2, 6, 9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis. Mol Cancer Ther. 2004 Mar. 3(3):353-62. | [3].Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994). | [4].Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995).
MolecularWeight
298.34
Research Area
Others
Solubility
DMSO : 100 mg/mL (335.19 mM; Need ultrasonic)
Target
CDK
Isoform
cdk2-cyclin A; cdk2-cyclin E; cdk5-p35
Pathway
Cell Cycle/DNA Damage

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
available

Delivery expected until 4/20/2023 

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