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(S,R,S)-AHPC-Me dihydrochloride

(S,R,S)-AHPC-Me dihydrochloride

Item no.	TMO-T13671L-50mg
Manufacturer	TargetMol
Amount	50 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 1 g 1 mL 2 g 500 mg 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Shipping Condition	Cool pack
Available
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	517, 51
Target names or alias	VHL ligand 2 dihydrochloride , (S, R, S)-AHPC-Me dihydrochloride (1948273-02-6 free base) , E3 ligase Ligand 1 dihydrochloride
Description	(S, R, S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S, R, S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
Pathways	Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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