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(S,R,S)-AHPC-Me dihydrochloride European Partner

Item no. TMO-T13671L-1ml
Manufacturer TargetMol
CASRN T13671L
Amount 1 mL
Quantity options 100 mg 1 mL x 10 mM (in DMSO) 1 g 1 mL 2 g 500 mg 50 mg
Category
Type Chemicals
Specific against other
Formula C23H34Cl2N4O3S
Smiles N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
ECLASS 10.1 32160000
ECLASS 11.0 32160000
UNSPSC 12000000
Alias VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Shipping Condition Cool pack
Available
Shipping Temperature
cool pack
Storage Conditions
-20°
Molecular Weight
517, 51
Description
(S, R, S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S, R, S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
Bioactivity
(S, R, S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S, R, S)-AHPC-Me
Pathways
Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 mL
Available: In stock
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