Comparison

Methoxyamine HCl

Manufacturer TargetMol
Category
Type Inhibitors
Specific against other
Amount 1g
Item no. TMO-T21320-1g
Approximate Leadtime 1-2 Weeks
eClass 6.1 30220300
eClass 9.0 32160605
Available
SMILES
CON.Cl
formula
CH6ClNO
MolWt
83.51
Bioactivity
Methoxyamine HCl covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. This agent may potentiate the anti-tumor activity of alkylating agents.
Reference
Yan T, Seo Y, Schupp JE, Zeng X, Desai AB, Kinsella TJ. Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence. Mol Cancer Ther. 2006 Apr; 5(4):893-902. PubMed PMID: 16648559.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 1g
Available: In stock
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