Cholesterol-5α,6α-epoxide

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Cholesterol-5α, 6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α, 6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE application.

5α, 6α-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.[1] 5α, 6α-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor β (LXRβ). [2] 5α, 6α-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.[1] Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer’s disease. [3]