« Back
Home /
Nutlin-3a

Nutlin-3a

Item no.	TMO-T6023-200mg
Manufacturer	TargetMol
CASRN	675576-98-4
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,9873
Formula	C30H30Cl2N4O4
Smiles	COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Autophagy\|\|\|Apoptosis\|\|\|E1/E2/E3 Enzyme
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	581.49
Description	Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.
Pathways	Autophagy\|\|\|Apoptosis\|\|\|Ubiquitination
Bioactivity	Nutlin-3a, the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TMO-T6023-200mg-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 200 mg

available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question