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CYC-116

CYC-116

Item no.	TMO-T6458-5mg
Manufacturer	TargetMol
CASRN	693228-63-6
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Smiles	Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	CDK\|\|\|Aurora Kinase\|\|\|VEGFR\|\|\|FLT\|\|\|S6 Kinase
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	368.46
Description	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 and SAPK2A. Phase 1.
Pathways	MAPK\|\|\|Chromatin/Epigenetic\|\|\|PI3K/Akt/mTOR signaling\|\|\|Tyrosine Kinase/Adaptors\|\|\|Cell Cycle/Checkpoint\|\|\|Angiogenesis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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