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Desmethyl Erlotinib hydrochloride

Desmethyl Erlotinib hydrochloride

Item no.	TMO-T6619-200mg
Manufacturer	TargetMol
CASRN	183320-51-6
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	0,9903
Formula	C21H22ClN3O4
Smiles	Cl.COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	OSI420,OSI-420,DesMethyl Erlotinib (CP-473420) HCl,CP-473420,Desmethyl Erlotinib,OSI 420
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Drug Metabolite\|\|\|EGFR
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	415.87
Description	Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
Pathways	JAK/STAT signaling\|\|\|Angiogenesis\|\|\|Tyrosine Kinase/Adaptors\|\|\|Metabolism
Bioactivity	OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 mg

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