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Vorinostat

Vorinostat

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Lineage Markers Aging & Neurological Disorders Neural Epigenetics Inhibitors & Compound Libraries Small Molecules By Organ Head & Neck Cancer Testicular & Prostate Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	10mM/1mL
Item no.	HY-10221-10mM
Targets	HDAC; Autophagy; Mitophagy; Filovirus; Apoptosis
CASRN	149647-78-9
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis[1][4]. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification[7].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	264.32
Clinical_Information	Launched
Manufacturers Research_Area	Cancer; Infection
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Apoptosis; Autophagy; Filovirus; HDAC; HPV; Mitophagy
Isoform	HDAC1; HDAC11; HDAC2; HDAC3; HDAC7
Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Reference compound

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HY-10221-10mM-safety-datasheet.pdf