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BIX-01294

BIX-01294

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer S100 Calcium Binding Protein B Markers
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	10mM/1mL
Item no.	HY-10587-10mM
Targets	Histone Methyltransferase; Autophagy
CASRN	935693-62-2
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1, 4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells[1][2][3][4][5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	490.64
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 110 mg/mL\|H2O : < 0.1 mg/mL (ultrasonic)
Manufacturers Target	Autophagy; Histone Methyltransferase
Isoform	EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C
Pathway	Autophagy; Epigenetics
Manufacturers Product type	Reference compound

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HY-10587-10mM-safety-datasheet.pdf