SCR7

Item no.	HY-12742-10mM
Manufacturer	MedChem Express
CASRN	1533426-72-0
Amount	10 mMx1 mL
Quantity options	10 mMx1 mL 10 mg 1 ea 50 mg 5 mg
Category	Oncology Neuroscience Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Type	Inhibitors
Specific against	other
Purity	98.22
Citations	BMC Biotechnol. 2021 Jul 27;21(1):45. EMBO Rep. 2019 Mar;20(3):e46821. J Genet Genomics. 2021 Mar 30. J Immunol. 2020 Apr 1;204(7):1904-1918. J Immunother Cancer. 2022 Jan;10(1):e003809. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Mol Ther Nucleic Acids. 2024 Jul 17;35(3):102274. Onco Targets Ther. 2018 Aug 17;11:4945-4953. Sens Actuators B Chem. 19 February 2022, 131598. Stem Cell Res Ther. 2024 Dec 2;15(1):458. Viruses. 2023 Nov 14, 15(11), 2256. Int J Mol Sci. 2022, 23(14), 7518. Virology. 2025 Mar 17:606:110504. [1]Srivastava M, et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012 Dec 21;151(7):1474-87. [2]Lin C, et al. Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep. 2016 Oct 7;6:34531. [3]Supriya V Vartak, et al. Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End Joining in a Ligase IV Dependent Manner. FEBS J. 2018 Nov;285(21):3959-3976.
Smiles	O=C(N1)C(/N=C/C2=CC=CC=C2)=C(NC1=S)/N=C/C3=CC=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1533426-72-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; CRISPR/Cas9; DNA/RNA Synthesis
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	334.39
Product Description	SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine (HY-107845). SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 45 mg/mL
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage
Clinical information	No Development Reported

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HY-12742-10mM-safety-datasheet.pdf