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Infigratinib

Infigratinib

Item no.	HY-13311-5mg
Manufacturer	MedChem Express
CASRN	872511-34-7
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 200 mg 500 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Uterine, Ovarian & Cervical Cancer Calcium Binding Protein Markers
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.82
Formula	C26H31Cl2N7O3
Citations	[1]Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T [2]Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42. [3]Liu H, et al. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discov. 2018 Mar;8(3):354-369.
Smiles	ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BGJ-398; NVP-BGJ398
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; FGFR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	560.48
Product Description	Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 12 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Isoform	FGFR1; FGFR2; FGFR3; FGFR4
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-13311-5mg-safety-datasheet.pdf