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Alpelisib

Alpelisib

Item no.	HY-15244-10mg
Manufacturer	MedChem Express
CASRN	1217486-61-7
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 500 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Breast Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.95
Citations	[1]Furet P, et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8.\|[2]Fritsch C, et al. Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther. 2014 May;13(5):1117-29.\|[3]Gobin B, et al. BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma. Int J Cancer. 2015 Feb 15;136(4):784-96. Am J Cancer Res. 2021 Mar 1;11(3):773-792.\|Biochem Biophys Res Commun. 2020 Sep 24;530(3):520-526.\|Biomaterials. 16 September 2022.\|Biomed Pharmacother. 2020 Sep;129:110397.\|Biomed Rep. 2023 Oct 13.\|Biomolecules. 2021 Jan 25;11(2):150.\|bioRxiv. 2020 Jan.\|bioRxiv. 2023 Aug 22.\|bioRxiv. 2023 May 30.\|bioRxiv. 2024 August 18.\|bioRxiv. 2024 July 07.\|bioRxiv. 2024 November 03.\|Biosci Rep. 2020 Oct 30;40(10):BSR20201128.\|Blood. 2019 Jan 3;133(1):70-80.\|Blood. 2024 Jul 5:blood.2023021705.\|Br J Cancer. 2022 Nov 1.\|Br J Haematol. 2020 May;189(4):731-744.\|Breast Cancer Res. 2021 May 21;23(1):57.\|Cancer Cell. 2023 Jun 12;41(6):1103-1117.e12.\|Cancer Cell. 2024 Jul 8;42(7):1286-1300.e8.\|Cancer Discov. 2020 Aug;10(8):1226-1239.\|Cancer Discov. 2023 Aug 25;CD-23-0396.\|Cancer Lett. 2019 Jan;440-441:54-63.\|Cancer Lett. 2024 Aug 10.\|Cancer Lett. 2024 Sep 5:217219.\|Cancer Metab. 2025 Feb 7;13(1):6.\|Cancer Nanotechnol. 2023 Mar 29.\|Cancer Res. 2021 Mar 8;canres.3232.2020.\|Cancers (Basel). 2022, 14(15), 3559.\|Cell Biosci. 2022 Dec 30;12(1):210.\|Cell Death Dis. 2020 Oct 6;11(10):831.\|Cell Death Dis. 2022 Jan 12;13(1):54.\|Cell Death Dis. 2023 Dec 14;14(12):831.\|Cell Metab. 2021 Nov 2;33(11):2247-2259.e6.\|Cell Rep. 2020 Sep 29;32(13):108196.\|Cell Rep. 2023 Dec 26;42(12):113535.\|Cell Rep. 2024 Apr 23;43(4):114088.\|Cell Rep. 2024 May 2;43(5):114174.\|Cell Syst. 2018 Apr 25;6(4):424-443.e7.\|Cell Syst. 2019 Jul 24;9(1):35-48.e5. \|Cell Syst. 2020 Jan 22;10(1):66-81.e11.\|Cells. 2022, 11(15), 2402.\|Diabetes. 2024 Sep 12:db240402.\|Endocrinology. 2023 Sep 13;bqad135.\|Front Oncol. 2021 Jul 13;11:704042.\|Front Oncol. 2021 Nov 24:11:766298.\|Gynecol Oncol. 2020 Dec;159(3):827-838.\|Harvard Medical School LINCS LIBRARY\|Int J Cancer. 2024 Jul 15;155(2):324-338.\|Int J Mol Sci. 2023 Aug 30, 24(17), 13418.\|Int J Mol Sci. 2019 Jul 10;20(14):3383. \|Int J Oncol. 2022 Apr;60(4):37.\|J Anal Sci Technol. 13, 31 (2022).\|J Clin Invest. 2021 Dec 15;131(24):e140436.\|J Exp Med. 2023 Nov 6;220(11):e20211743.\|J Exp Med. 2023 Nov 6;220(11):e20230926.\|J Hematol Oncol. 2020 Feb 22;13(1):13.\|J Med Chem. 2024 Aug 19.\|J Proteome Res. 2021 Apr 26.\|J Transl Med. 2022 Jun 7;20(1):263.\|JCI Insight. 2022 Jul 19;e155899.\|Mol Cancer Res. 2020 Jun;18(6):822-834.\|Mol Psychiatry. 2021 Apr 30.\|Molecules. 2020 Apr 23;25(8):1980.\|Nat Aging. 2023 Jan 23.\|Nat Biomed Eng. 2018 Aug;2(8):578-588.\|Nat Commun. 2020 Aug 13;11(1):4053.\|Nat Commun. 2022 Jan 11;13(1):245.\|Nat Commun. 2023 Jul 13;14(1):4084.\|Nature Cancer. 2021 Jan;2(1):34-48.\|Nature. 2018 Jun;558(7711):540-546. \|Neoplasia. 2023 Jun 20;43:100913.\|Oncogene. 2016 Jul 7;35(27):3607-12. \|Oncol Rep. 2019 Nov;42(5):2097-2107.\|Patent. US20220249511A1.\|Patent. US20220313694A1.\|PLoS One. 2024 Aug 2;19(8):e0308051.\|Preprints. 2024 Feb 16.\|Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2215621119.\|Research Square Preprint. 2020 Aug.\|Research Square Preprint. 2022 Jan.\|Research Square Preprint. 2023 May 10.\|Research Square Preprint. 2023 May 9.\|RSC Adv. 2024 Oct 18;14(45):32876-32882.\|Sci Adv. 2022 Dec 9;8(49):eade7823.\|Sci Rep. 2021 Jan 11;11(1):291.\|Sci Rep. 2025 Jan 18;15(1):2415.\|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.\|Sci Transl Med. 2021 Oct 6;13(614):eabg0809.\|Science. 2017 Dec 1;358(6367):eaan4368.\|Science. 2021 Oct;374(6563):eabf3067.\|Signal Transduct Target Ther. 2024 Jun 17.\|STAR Protoc. 2023 Nov 16;4(4):102683.\|Ther Adv Med Oncol. 2020 Dec 14;12:1758835920975621.\|University of Cologne. 2024.\|Cancers (Basel). 2022, 14(1), 214.
Smiles	CC(N=C(S1)NC(N2CCC[C@H]2C(N)=O)=O)=C1C3=CC(C(C)(C(F)(F)F)C)=NC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BYL-719
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	441.47
Product Description	Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 83.33 mg/mL (ultrasonic)
Manufacturer - Pathway	PI3K/Akt/mTOR
Isoform	PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Clinical information	Launched

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HY-15244-10mg-safety-datasheet.pdf