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Donepezil (Hydrochloride)

Donepezil (Hydrochloride)

Item no.	HY-B0034-100mg
Manufacturer	MedChem Express
CASRN	120011-70-3
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 1 g 200 mg 25 mg 500 mg 50 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer
Type	Inhibitors
Specific against	other
Purity	99.92
Citations	[1]H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13.\|[2]Min-Young Noh,et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25.\|[3]Chang Yell Shin, et al. The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Biomol Ther (Seoul). 2018 May 1;26(3):274-281. Alzheimers Res Ther. 2025 Feb 14;17(1):43.\|Clin Transl Med. 2021 May 28.\|J Integr Neurosci. 2023 May 16, 22(3), 76.\|Patent. US20210378961A1.\|Research Square Preprint. 2024 Apr 23.\|bioRxiv. 2024 Dec 23:2024.12.22.629999.\|Chem Biodivers. 2025 Jan 7:e202402771.\|Comput Struct Biotec. 2023 Feb 24.\|Eur J Med Chem. 2023 Dec 21, 116071.\|Foods. 2022, 11(14), 2095.\|J Ethnopharmacol. 2024 Nov 9;338(Pt 1):119017.\|J Ethnopharmacol. 2025 Mar 10:119619.\|Journal of Pharmaceutical Investigation. 2021 Mar 31.\|Phytomedicine. 2024 Jun 4:131:155802.
Smiles	O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	E2020
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Cholinesterase (ChE)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	415.95
Product Description	Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 6.2 mg/mL (warming)\|H2O: 25 mg/mL (ultrasonic)
Manufacturer - Pathway	Neuronal Signaling
Isoform	AChE
Clinical information	Launched

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HY-B0034-100mg-safety-datasheet.pdf