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Ranitidine (hydrochloride)

Ranitidine (hydrochloride)

Item no.	HY-B0281A-10mM
Manufacturer	MedChem Express
CASRN	66357-59-3
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 500 mg
Category	Food Safety Histamines Cell Biology Cytoskeleton Inhibitors & Compound Libraries Small Molecules small GTPases Ran Subfamily
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.88
Formula	C13H23ClN4O3S
Citations	[1]Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9. [2]Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81. [3] Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.
Smiles	CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	66357-59-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Bacterial; Cytochrome P450; Histamine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	350.86
Product Description	Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].
Manufacturer - Research Area	Infection; Endocrinology; Metabolic Disease; Cancer; Cardiovascular Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : ≥ 50 mg/mL
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	CYP2; H2 Receptor
Clinical information	Launched

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HY-B0281A-10mM-safety-datasheet.pdf