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Sulfisoxazole

Sulfisoxazole

Item no.	HY-B0323-10mM
Manufacturer	MedChem Express
CASRN	127-69-5
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Food Safety Antibiotics Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.\|[2]Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.\|[3]Shin JM, et al. Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD-L1. Adv Sci (Weinh). 2022 Feb;9(5):e2103245. \|[4]Syed H, et al. Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide. Neurochem Int. 2006 Jun;48(8):708-17.
Smiles	O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Sulfafurazole
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Antibiotic; Bacterial; Endothelin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	267.30
Product Description	Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
Manufacturer - Research Area	Cancer; Infection; Endocrinology
Solubility	DMSO: ≥ 150 mg/mL
Manufacturer - Pathway	Anti-infection; GPCR/G Protein
Isoform	ETA; ETB
Clinical information	Launched

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HY-B0323-10mM-safety-datasheet.pdf