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Bruceantin

Bruceantin

Item no.	HY-N0840-5mg
Manufacturer	MedChem Express
CASRN	41451-75-6
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Colorectal Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Cuendet M, et al. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 1;10(3):1170-9.\|[2]Cuendet M, et al. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb;67(2):269-72.\|[3]Gillin FD, et al., Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica. Antimicrob Agents Chemother. 1982 Aug;22(2):342-5.
Smiles	O=C([C@@]1([C@H]([C@H](O)[C@]2([H])[C@]3(C4)C)O)[C@@]([C@H](C5=O)OC(/C=C(C)/C(C)C)=O)([H])[C@@]2([C@@](O5)([H])C[C@@]3([H])C(C)=C(O)C4=O)CO1)OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(-)-Bruceantin,NCI165563,NSC165563
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Caspase; c-Myc; Mitochondrial Metabolism; Parasite
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	548.58
Product Description	Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities[1][2][3].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-N0840-5mg-safety-datasheet.pdf