AZ 10606120 dihydrochloride

Non Antibodies

P2X7 channels

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

495, 49

A Potent and Selective Antagonist of P2X7 Receptors

Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).

41116134

AZ 10606120 dihydrochloride is a potent and selective non-competitive antagonist of P2X7 receptors, acting as a negative allosteric modulator shown to inhibit human P2X7 receptors with pIC50 of 8.1-8.91-3. It also inhibits growth and neoangiogenesis of P2X7-expressing tumors in mice4.

Yes

AZ 10606120 dihydrochloride is a potent and selective noncompetitive antagonist of the P2X7 receptor with IC50 value of ~10 nM2. The compound shows little or no effect at other P2X receptor subtypes1, 2. In studies conducted in animal models, AZ 10606120 treatment shows antidepressant effects and reduces tumor growth2.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. Seven members of this family have been identified and function in homomeric or heteromeric combinations. P2X7 receptor is a therapeutic target due to its potential involvement in pain and inflammatory disorders1, 2.