A23187

Non Antibodies

Israel

Storage as Solution: Up to one week at 4°C or three months at -20°C.Protect from light. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Lyophilized Powder

Calcimycin, Calcium ionophore A23187 - Widely Used Ca2+ Ionophore

7, 4

Streptomyces chartreusis.

A23187 is a mobile-carrier Ca2+ ionophore and can cause cell activation, differentiation, or proliferation and thus mimics cellular processes observed in response to cytokines and growth factors1, 2. Furthermore, A23187 induces, in a concentration- and time-dependent manner, Ca2+ triggered cell apoptosis3, 4.

Yes

A23187 is a mobile-carrier Ca2+ ionophore (allows Ca2+ ions to cross cell membranes) originally isolated as an antibiotic from Streptomyces chartreusensis. It is used to increase intracellular Ca2+ levels and for in vitro studies related to intracellular Ca2+-mediated events. A23187 can cause cell activation, differentiation, or proliferation and thus mimics cellular processes observed in response to cytokines and growth factors.1, 2Furthermore, A23187 induces, in a concentration- and time-dependent manner, Ca2+-triggered cell apoptosis.3, 4 This property was exploited to clarify apoptotic events in different cell lines such as mouse lymphoma cell line (S49), 5, 6 histiocytic lymphoma U937, 7 human myeloid leukemia cells (HL-60), 8 cultured striatal neurons, 9 renal tubular cells, 10 and C6 glioma cells.11