Bilobalide

S. Molecules

Israel

Storage as Solution: Up to four weeks at 4°C or three months at -20°C. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Lyophilized Powder

An Antagonist of 5-HT3A and GABA(A) Receptors

7, 4

Ginkgo biloba.

Bilobalide is a 5-HT3A1 and GABAA2 channel blocker.

Yes

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the Cys-loop channel family1.The GABA(A) receptor is also a ligand-gated ion channel. It is the major receptor type for the GABA inhibitory neurotransmitter in the central nervous system2.Bilobalide is a natural non-selective blocker of the 5-HT3A and GABA(A) channels. Bilobalide is a sesquiterpene trilactone extracted from the leaves of the tree Ginkgo biloba. Bilobalide has an effective concentration of 1-100 μM and an IC50 of 470 μM for the 5-HT3A receptor3 and an IC50 of 4.6±0.5 μM for the GABA(A) receptor. Bilobalide also binds to other anion Cys-loop receptors such as glycine receptors with a much higher affinity than to the 5-HT3A receptor.Bilobalide inhibits direct GABA mediated currents from recombinant human GABA(A) receptors thus suggesting it enhances neuronal excitability. Bilobalide is used in traditional Japanese medicine as a memory enhancer, treating symptoms associated with mild-moderate dementia and improving cognitive functions related to old age and senility3.