CPCCOEt

Non Antibodies

mGluR1

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

247, 25

A Selective, Non-Competitive Antagonist of mGluR1 Receptors

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

CPCCOEt is a selective, non-competitive antagonist of mGluR1 receptors, inhibiting hmGluR1b with IC50 of 6.5 µM, whilst having no effect at 100 µM on a range of other receptor subtypes1. It was shown to inhibit synaptic activation of mGluR1 in Purkinje cell cerebellar slices with IC50 of 37µM2.

Yes

CPCCOEt is a compound that acts as a selective, non-competitive antagonist of mGluR1. It can inhibit mGluR1 signaling without affecting glutamate binding1. CPCCOEt selectively inhibits mGluR1b-induced increases in intracellular calcium and demonstrates IC50 of 6.5 µM1.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating metabotropic glutamate receptors (mGluRs), members of the G-protein coupled receptor (GPCR) superfamily. These receptors are divided into three groups based on sequence homology with a total of eight subtypes, mGluR1 to mGluR8.mGluR1 from group I, plays an important role in the central sensitization of pain and in a variety of physiological functions including regulation of ion channels, synaptic transmission, and plasticity1, 2.