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CAY10593 (VU0155069)

CAY10593 (VU0155069)

Item no.	ALO-C-385-5mg
Manufacturer	Alomone
CASRN	1130067-06-9
Amount	5 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Fatty Acid Catabolism Reagents & Chemicals Molecules
Type	Small Molecules
Format	Lyophilized
Specific against	other
Purity	>95%
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Non Antibodies
Manufacturer - Category	S. Molecules
Manufacturer - Targets	P2X7 receptors, Phospholipase D1 (PLD1)
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage as Solution: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	462, 98
Manufacturer - Format	Lyophilized Powder
Short description	An Antagonist of P2X7 Receptors and an Inhibitor of Phospholipase D1
Description	(S)-N-(1-(4-(5-Chloro-2-oxo-2, 3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide. - An Antagonist of P2X7 Receptors and an Inhibitor of Phospholipase D1
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
PH	7, 4
UNSPSC	41116134
Effective Concentration	1-10 µM.
Activity	CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors, shown to inhibit ATP-induced ethidium+ uptake in RPMI 8226 cells with IC50 of 2 µM1. It is also a potent and selective inhibitor of phospholipase D1 (IC50 of 46 and 933 nM for PLD1 and PLD2, respectively)2.
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Bioassay tested	Yes
Chemical Name	N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]naphthalene-2-carboxamide.
Scientific Background	CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors and an inhibitor of phospholipase D1 (PLD1)1. CAY10593 inhibits ATP-induced ethidium+ uptake in RPMI 8226 cells expressing P2X7 receptors in a concentration-dependent manner with an IC50 value of 2 µM1.The P2X receptors are a family of ligand-gated ion channels present on various cell types. P2X receptors are activated by extracellular ATP and play an important role in many disease states, including inflammatory, immune, neoplastic, musculoskeletal, and neurological disorders1, 2.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ALO-C-385-5mg-safety-datasheet.pdf