FTX-3.3

Non Antibodies

P-type Ca2+ channels

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

273, 4

A Blocker of P-Type CaV Channels

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

41116134

Agelenopsis aperta (North American funnel-web spider).

FTX-3.3 is a synthetic polyamine1-2, reputed to be structurally identical to the native Funnel Web Spider Toxin (FTX). It blocks P-, N-, and L-type Ca2+ channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies3.

Yes

FTX is a polyamine component of the venom of the American funnel web spider Agelenopsis aperta, and has been described as a selective antagonist of P-type voltage-dependent Ca2+ channels1-2. However, it has been demonstrated that FTX has actions at other sites including NMDA and GABA receptors and also on T-type calcium channels3.FTX-3.3 (reputed to be structurally identical to the native FTX) has been synthesized4-5 and shown to block P-type calcium channels in rat cerebellar Purkinje cells6. It antagonizes P-, N-, and L-type calcium channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies; Its IC50 against P-, N-, and L-type channels are ~0.13 mM, ~0.24 mM and ~0.24 mM, respectively7.FTX-3.3 does not reduce whole-cell sodium current recorded from SK.N.SH cells and is therefore ion selective8.